The Future of Disease Detection

Biomarkers

Biomarkers Identify Diseases

The molecular markers in your blood can be measured in your breath.

Facts:

  • There exists a blood-breath interface in the lungs called alveoli.
  • Molecules diffuse out of blood and into breath.

Breathtec aims to deliver a non-invasive, alternative diagnostic screening aid for various health-related concerns including certain cancers, liver disease, kidney failure, diabetes, asthma and tuberculosis.

These diseases (and more) all produce distinctive signatures in the breath which can be distinguished using our innovative technology.

Blood-Air Barrier: Biomarker nexus

The blood–air barrier (alveolar–capillary barrier or membrane) exists in the gas exchanging region of the lungs. It exists to prevent air bubbles from forming in the blood, and from blood entering the alveoli. It is formed by the type 1 pneumocystis of the alveolar wall, the endothelial cells of the capillaries and the basement membrane between the two cells. The barrier is permeable to molecular oxygen, carbon dioxide, carbon monoxide and many other gases. This blood gas barrier is extremely thin (approximately 2μm-600 nm; in some places merely 200 nm) to allow sufficient oxygen diffusion, yet it is extremely strong.

Alveoli

The Alveoli – Key to Biomarker detection

An alveolus (plural: alveoli, from Latin alveolus, “little cavity”) is an anatomical structure that has the form of a hollow cavity. Found in the lung parenchyma, the pulmonary alveoli are the terminal ends of the respiratory tree, which outcrop from either alveolar sacs or alveolar ducts, which are both sites of gas exchange with the blood as well. Alveoli are particular to mammalian lungs. The alveolar membrane is the gas-exchange surface. Carbon dioxide rich blood is pumped from the rest of the body into the alveolar blood vessels where, through diffusion, it releases its carbon dioxide and absorbs oxygen. A typical pair of human lungs contain about 700 million alveoli, producing 70m2 of surface area. Each alveolus is wrapped in a fine mesh of capillaries covering about 70% of its area.

Alveolus