Planning Phase II Trial
VANCOUVER, BC – (November 13, 2018) – Nash Pharmaceuticals Inc., a wholly owned subsidiary of Breathtec Biomedical Inc. (CSE: BTH) (CNSX: BTH) (FRANKFURT: BTI) (OTCQB: BTHCF) (the “Company” or “Nash Pharma”) is pleased to announce that one of its lead compounds for Inflammatory Bowel Disease (“IBD”) NP-178 showed positive results in a recently completed study investigating its therapeutic effects in an ulcerative colitis mouse model. NP-178 is one of a number of already approved compounds that Nash Pharma has been screening for new therapeutic uses as part of its drug repurposing strategy. Repurposing drugs offer several benefits over traditional drug development including a reduction in investment and risk, shorter research periods and a longer active patent life.
Data from this study demonstrated statistically significant improvements in multiple measurements over multiple timepoints relevant to ulcerative colitis including:
- Body weight, stool consistency, colon length and weight ratios and occult positivity (p<0.001 to p<0.05)
- The drug compared very favourably to the control, 5-ASA, the current standard of care for IBD.
- No negative side effects were observed.
- NP-178 is a repurposed, orally delivered neurological drug.
“The IBD market segment represents an enormous unmet medical need globally and there is a particular interest in orally delivered compounds exhibiting new mechanisms of action,” said Christopher J. Moreau CEO of Nash Pharma. “We plan to present our preclinical in vivo IBD results at an upcoming conference and will update the market on plans for a Phase IIa study for our leading repurposed IBD candidate in 2019 pending additional results shortly.”
The Global Inflammatory Bowel Diseases (IBD) Drug Market Forecast 2018-2028 Report shows that the global inflammatory bowel diseases (IBD) drug market is estimated at $6.7bn in 2017 and $7.6bn in 2023. Biologic therapies held 57% share of the IBD market in 2017. The antibiotics segment of the IBD market is estimated to grow at a CAGR of 6.3% from 2018-2023.
About Nash Pharmaceuticals Inc.
Nash Pharma is a wholly owned subsidiary of Breathtec Biomedical Inc. Nash Pharma is a clinical stage pharmaceutical development company focused on drug repurposing in the areas of non–alcoholic steatohepatitis (NASH), chronic kidney disease (CKD) and inflammatory bowel disease (IBD). Drug repurposing is the process of discovering new therapeutic uses for existing drugs.
For more information, visit https://nashpharmaceuticals.com/.
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